Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetPlasminogen activator-induced lysis of fibrin clots

General description

A 452-amino acid glycoprotein present in plasma at about 70 µg/ml. Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Forms a covalent complex with plasmin and inactivates it.

A 452-amino acid glycoprotein present in plasma at about 70 µg/ml. Efficiently inhibits the plasminogen activator-induced lysis of fibrin clots. Forms a covalent complex with plasmin and inactivates it.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Schaefer, B.M., et al. 1996. Arch. Dermatol. Res. 288, 122.Aoki, N., et al. 1980. Blood 55, 483.Saito, H., et al. 1974. Circ. Res.34, 641.

Packaging

100 µg in Plastic ampoule

Physical form

Lyophilized from 200 mM NaCl, 20 mM Bis-Tris, pH 6.4.

Preparation Note

Please refer to the vial label for the lot-specific reconstitution volume.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Unit Definition

One Inhibitory Unit (I.U.) is defined as the amount of enzyme that will inhibit 1 unit plasmin activity using tosyl-Gly-Pro-Lys-pNA as substrate at 25°C, pH 7.8

Warning

Toxicity: Standard Handling (A)